Bioactive sucrose esters from Bidens parviflora

An investigation on Bidens parviflora led to the isolation of three sucrose esters and a substituted truxillate. Their structures were elucidated as (6- O-( E) -p-coumaroyl)-β- d-fructofuranosyl-(2→1)-α- d-glucopyranoside, (6 -O-( E) -p-coumaroyl)-β- d-fructofuranosyl-(2→1)-(6 -O-( E) -p-coumaroyl)-α- d-glucopyranoside II, 6,6′-sucrose ester of (1α,2α,3β,4β)-3,4-bis(4-hydroxyphenyl)-1,2-cyclobutanedicarboxylic acid, dimethyl ester of (1α,2α,3α,4α)-2,4-bis(3,4-dihydroxyphenyl)-1,3-cyclobutanedicarboxylic acid on the basis of spectral and chemical evidence. These compounds were subjected to the following bioassays: the histamine release inhibition of rat mast cells induced by antigen-antibody reaction and the inhibitory activity of PGE 2 production by macrophages. Three sucrose esters and a substituted truxillate were isolated from Bidens parviflora Willd.