Cytotoxic Activity of Natural Labdanes and their Semi-Synthetic Modified Derivatives from Croton oblongifolius

Abstract Labda-7,12(E),14-triene-17-oic acid, previously isolated from CROTON OBLONGIFOLIUS, and its derivatives were investigated for cytotoxicity against five human tumor cell lines. Six of these compounds, labda-7,12(E),14-triene-17-al, 17-hydroxylabda-7,12(E),14-triene, 17-acetoxylabda-7,12(E),1...

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Veröffentlicht in:	Planta medica 2003-02, Vol.69 (2), p.167-170
Hauptverfasser:	Sommit, Damrong, Petsom, Amorn, Ishikawa, Tsutomu, Roengsumran, Sophon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Breast Neoplasms - drug therapy Croton Diterpenes - administration & dosage Diterpenes - pharmacology Diterpenes - therapeutic use General pharmacology Humans Letter Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Bark Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Stomach Neoplasms - drug therapy Tumor Cells, Cultured - drug effects
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Zusammenfassung:	Abstract Labda-7,12(E),14-triene-17-oic acid, previously isolated from CROTON OBLONGIFOLIUS, and its derivatives were investigated for cytotoxicity against five human tumor cell lines. Six of these compounds, labda-7,12(E),14-triene-17-al, 17-hydroxylabda-7,12(E),14-triene, 17-acetoxylabda-7,12(E),14-triene, 15-hydroxylabda-7,13(E)-diene-17,12-olide, labda-7,13(E)-diene-17,12-olide, and 12,17-dihydroxylabda-7,13(E)-diene showed non-specific, moderate, cytotoxicity against all cell lines, whereas the other compounds were inactive.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2003-37708