The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug

The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2003-01 (1), p.122-123
Hauptverfasser:	Davies, Murray S, Berners-Price, Susan J, Cox, John W, Farrell, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Cross-Linking Reagents DNA - chemistry DNA Adducts - chemistry DNA, Single-Stranded - chemistry Kinetics Magnetic Resonance Spectroscopy Organoplatinum Compounds - chemistry Templates, Genetic
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Zusammenfassung:	The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
ISSN:	1359-7345
DOI:	10.1039/b209661g