New generation of sterically protected C18 stationary phases containing embedded urea groups for use in high-performance liquid chromatography

New monofunctional C18 urea stationary phases with sterically protecting dimethyl and diisopropyl groups were prepared by a single step modification process. ProntoSil spherical silica (3 microm) was chemically modified with the monofunctional ethoxysilanes, [(3-octadecylurea)propyl]dimethyl and [(3...

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Veröffentlicht in:	Journal of Chromatography A 2003-02, Vol.987 (1-2), p.127-138
Hauptverfasser:	SILVA, César Ricardo, SALES FONTES JARDIM, Isabel Cristina, AIROLDI, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical chemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid - instrumentation Exact sciences and technology General pharmacology Magnetic Resonance Spectroscopy Medical sciences Other chromatographic methods Pharmacology. Drug treatments Spectrophotometry, Infrared Urea - chemistry
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Zusammenfassung:	New monofunctional C18 urea stationary phases with sterically protecting dimethyl and diisopropyl groups were prepared by a single step modification process. ProntoSil spherical silica (3 microm) was chemically modified with the monofunctional ethoxysilanes, [(3-octadecylurea)propyl]dimethyl and [(3-octadecylurea)propyl]diisopropyl ethoxysilanes. The phases were characterized by elemental analysis, infrared and solid-state 29Si and 13C NMR spectroscopies. Chromatographic characterizations of the new phases in 50x3.9 mm HPLC columns were performed by the separation of two different test mixtures, containing nonpolar, polar and highly basic compounds.
ISSN:	0021-9673
DOI:	10.1016/s0021-9673(02)01807-1