Fatal influenza A virus infection in a child vaccinated against influenza

We report a fatal infection with influenza A virus in a 13-year-old child who had been vaccinated against influenza. Influenza A virus RNA was detected by PCR in lungs, bronchi and myocardium. A penicillin-sensitive strain of Staphylococcus aureus was also isolated from her bronchi. This case indica...

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Veröffentlicht in:	The Pediatric infectious disease journal 2003-02, Vol.22 (2), p.201-202
Hauptverfasser:	Thomas, Peter, Riffelmann, Marion, Schweiger, Brunhilde, Dominik, Sabine, von König, C H. Wirsing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Anti-Bacterial Agents Autopsy Biological and medical sciences Drug Therapy, Combination - therapeutic use Fatal Outcome Female Human viral diseases Humans Infectious diseases Influenza A virus - isolation & purification Influenza Vaccines - administration & dosage Influenza, Human - complications Influenza, Human - drug therapy Influenza, Human - prevention & control Medical sciences Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Pneumonia, Viral - drug therapy Polymerase Chain Reaction Risk Assessment Staphylococcal Infections - complications Staphylococcal Infections - diagnosis Staphylococcal Infections - drug therapy Superinfection - complications Superinfection - diagnosis Superinfection - drug therapy Viral diseases Viral diseases of the respiratory system and ent viral diseases
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Zusammenfassung:	We report a fatal infection with influenza A virus in a 13-year-old child who had been vaccinated against influenza. Influenza A virus RNA was detected by PCR in lungs, bronchi and myocardium. A penicillin-sensitive strain of Staphylococcus aureus was also isolated from her bronchi. This case indicates that a primary viral pneumonia with influenza A virus complicated by a bacterial superinfection with S. aureus can run a fatal course even in a vaccinated child.
ISSN:	0891-3668 1532-0987
DOI:	10.1097/01.inf.0000048962.53410.04