L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE
A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to b...
Gespeichert in:
| Veröffentlicht in: | Journal of antibiotics 1992/05/25, Vol.45(5), pp.679-685 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 685 |
|---|---|
| container_issue | 5 |
| container_start_page | 679 |
| container_title | Journal of antibiotics |
| container_volume | 45 |
| creator | ONDEYKA, J. HENSENS, O. D. ZINK, D. BALL, R. LINGHAM, R. B. BILLS, G. DOMBROWSKI, A. GOETZ, M. |
| description | A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme. |
| doi_str_mv | 10.7164/antibiotics.45.679 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73056430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73056430</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3</originalsourceid><addsrcrecordid>eNqFkM1q4zAUhUWZ0kl_XmBgQIthVnWqf0tLJySNqYlLkxZmJWRZmnFwko6VLPr2VXFIs-tGWpzv3nP5APiB0TDFgt2Zza6pmu2usWHI-FCk6gwMsJQ4wUyob2CAEMGJlAR9B5chrBCiKU3lBbjAgjCaogEYFYlQ4haylN3CDM7Ll0kBx3-W5XiWFdkin8NsAbM5zOezfJQvyydYTuEsf0kwfHwql5NsMbkG5960wd0c_ivwPJ0sx7OkKO_zcVYklnGsEsYssSre5QhFTrhaEVzbSlaVrzjjxCufEi49Zs556jGqsK2R9zzygtSGXoHf_d7Xbvt_78JOr5tgXduajdvug04p4oJR9CUY1SkqBIkg6UHbbUPonNevXbM23ZvGSH8Y1ieGNeM6Go5DPw_b99Xa1Z8jvdKY_zrkJljT-s5sbBOOGKNcKYkj9tBjq7Azf90xN10sa91pM1ZCfrTz_olHHCn7z3Tabeg7X4-aUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16493662</pqid></control><display><type>article</type><title>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>ONDEYKA, J. ; HENSENS, O. D. ; ZINK, D. ; BALL, R. ; LINGHAM, R. B. ; BILLS, G. ; DOMBROWSKI, A. ; GOETZ, M.</creator><creatorcontrib>ONDEYKA, J. ; HENSENS, O. D. ; ZINK, D. ; BALL, R. ; LINGHAM, R. B. ; BILLS, G. ; DOMBROWSKI, A. ; GOETZ, M.</creatorcontrib><description>A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.679</identifier><identifier>PMID: 1624370</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>AIDS/HIV ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Applied microbiology ; Ascomycota - chemistry ; Biological and medical sciences ; Chemotherapic agents ; Cytochalasins - chemistry ; Cytochalasins - isolation & purification ; Cytochalasins - pharmacology ; Fundamental and applied biological sciences. Psychology ; HIV Protease Inhibitors ; human immunodeficiency virus 1 ; Isoindoles ; Microbiology</subject><ispartof>The Journal of Antibiotics, 1992/05/25, Vol.45(5), pp.679-685</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4359981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1624370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ONDEYKA, J.</creatorcontrib><creatorcontrib>HENSENS, O. D.</creatorcontrib><creatorcontrib>ZINK, D.</creatorcontrib><creatorcontrib>BALL, R.</creatorcontrib><creatorcontrib>LINGHAM, R. B.</creatorcontrib><creatorcontrib>BILLS, G.</creatorcontrib><creatorcontrib>DOMBROWSKI, A.</creatorcontrib><creatorcontrib>GOETZ, M.</creatorcontrib><title>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.</description><subject>AIDS/HIV</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Ascomycota - chemistry</subject><subject>Biological and medical sciences</subject><subject>Chemotherapic agents</subject><subject>Cytochalasins - chemistry</subject><subject>Cytochalasins - isolation & purification</subject><subject>Cytochalasins - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Protease Inhibitors</subject><subject>human immunodeficiency virus 1</subject><subject>Isoindoles</subject><subject>Microbiology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1q4zAUhUWZ0kl_XmBgQIthVnWqf0tLJySNqYlLkxZmJWRZmnFwko6VLPr2VXFIs-tGWpzv3nP5APiB0TDFgt2Zza6pmu2usWHI-FCk6gwMsJQ4wUyob2CAEMGJlAR9B5chrBCiKU3lBbjAgjCaogEYFYlQ4haylN3CDM7Ll0kBx3-W5XiWFdkin8NsAbM5zOezfJQvyydYTuEsf0kwfHwql5NsMbkG5960wd0c_ivwPJ0sx7OkKO_zcVYklnGsEsYssSre5QhFTrhaEVzbSlaVrzjjxCufEi49Zs556jGqsK2R9zzygtSGXoHf_d7Xbvt_78JOr5tgXduajdvug04p4oJR9CUY1SkqBIkg6UHbbUPonNevXbM23ZvGSH8Y1ieGNeM6Go5DPw_b99Xa1Z8jvdKY_zrkJljT-s5sbBOOGKNcKYkj9tBjq7Azf90xN10sa91pM1ZCfrTz_olHHCn7z3Tabeg7X4-aUA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>ONDEYKA, J.</creator><creator>HENSENS, O. D.</creator><creator>ZINK, D.</creator><creator>BALL, R.</creator><creator>LINGHAM, R. B.</creator><creator>BILLS, G.</creator><creator>DOMBROWSKI, A.</creator><creator>GOETZ, M.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE</title><author>ONDEYKA, J. ; HENSENS, O. D. ; ZINK, D. ; BALL, R. ; LINGHAM, R. B. ; BILLS, G. ; DOMBROWSKI, A. ; GOETZ, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4519-44c2c9469e230e6ed921dcb8bbfb5452f9f7258f14eef3f10b1cd0ff5e2362da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>AIDS/HIV</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Ascomycota - chemistry</topic><topic>Biological and medical sciences</topic><topic>Chemotherapic agents</topic><topic>Cytochalasins - chemistry</topic><topic>Cytochalasins - isolation & purification</topic><topic>Cytochalasins - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV Protease Inhibitors</topic><topic>human immunodeficiency virus 1</topic><topic>Isoindoles</topic><topic>Microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ONDEYKA, J.</creatorcontrib><creatorcontrib>HENSENS, O. D.</creatorcontrib><creatorcontrib>ZINK, D.</creatorcontrib><creatorcontrib>BALL, R.</creatorcontrib><creatorcontrib>LINGHAM, R. B.</creatorcontrib><creatorcontrib>BILLS, G.</creatorcontrib><creatorcontrib>DOMBROWSKI, A.</creatorcontrib><creatorcontrib>GOETZ, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ONDEYKA, J.</au><au>HENSENS, O. D.</au><au>ZINK, D.</au><au>BALL, R.</au><au>LINGHAM, R. B.</au><au>BILLS, G.</au><au>DOMBROWSKI, A.</au><au>GOETZ, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>5</issue><spage>679</spage><epage>685</epage><pages>679-685</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>1624370</pmid><doi>10.7164/antibiotics.45.679</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1992/05/25, Vol.45(5), pp.679-685 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73056430 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | AIDS/HIV Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascomycota - chemistry Biological and medical sciences Chemotherapic agents Cytochalasins - chemistry Cytochalasins - isolation & purification Cytochalasins - pharmacology Fundamental and applied biological sciences. Psychology HIV Protease Inhibitors human immunodeficiency virus 1 Isoindoles Microbiology |
| title | L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T04%3A06%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=L-696,%20474,%20A%20NOVEL%20CYTOCHALASIN%20AS%20AN%20INHIBITOR%20OF%20HIV-1%20PROTEASE:%20II.%20ISOLATION%20AND%20STRUCTURE&rft.jtitle=Journal%20of%20antibiotics&rft.au=ONDEYKA,%20J.&rft.date=1992&rft.volume=45&rft.issue=5&rft.spage=679&rft.epage=685&rft.pages=679-685&rft.issn=0021-8820&rft.eissn=1881-1469&rft.coden=JANTAJ&rft_id=info:doi/10.7164/antibiotics.45.679&rft_dat=%3Cproquest_cross%3E73056430%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16493662&rft_id=info:pmid/1624370&rfr_iscdi=true |