L-696, 474, A NOVEL CYTOCHALASIN AS AN INHIBITOR OF HIV-1 PROTEASE: II. ISOLATION AND STRUCTURE

A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to b...

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Veröffentlicht in:	Journal of antibiotics 1992/05/25, Vol.45(5), pp.679-685
Hauptverfasser:	ONDEYKA, J., HENSENS, O. D., ZINK, D., BALL, R., LINGHAM, R. B., BILLS, G., DOMBROWSKI, A., GOETZ, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascomycota - chemistry Biological and medical sciences Chemotherapic agents Cytochalasins - chemistry Cytochalasins - isolation & purification Cytochalasins - pharmacology Fundamental and applied biological sciences. Psychology HIV Protease Inhibitors human immunodeficiency virus 1 Isoindoles Microbiology
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Beschreibung
Zusammenfassung:	A novel HIV-1 protease inhibitor, L-696, 474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696, 474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.679