Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: Structural deterioration and compensatory mechanisms

The progression of compensated hypertrophy to heart failure (HF) is still debated. We investigated patients with isolated valvular aortic stenosis and differing degrees of left ventricular (LV) systolic dysfunction to test the hypothesis that structural remodeling, as well as cell death, contributes...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2003-02, Vol.107 (7), p.984-991
Hauptverfasser:	HEIN, Stefan, ARNON, Eyal, KOSTIN, Sawa, SCHÖNBURG, Markus, ELSÄSSER, Albrecht, POLYAKOVA, Victoria, BAUER, Erwin P, KLÖVEKORN, Wolf-Peter, SCHAPER, Jutta
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aortic Valve Stenosis - complications Aortic Valve Stenosis - pathology Aortic Valve Stenosis - physiopathology Biological and medical sciences Capillaries - anatomy & histology Capillaries - chemistry Cardiology. Vascular system Cardiomegaly - complications Cardiomegaly - pathology Cardiomegaly - physiopathology Cell Death Cell Nucleus - genetics Disease Progression DNA - analysis Female Fibrosis Heart Heart Failure - etiology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hemodynamics Humans Inflammation - etiology Male Medical sciences Models, Cardiovascular Myocytes, Cardiac - pathology Myocytes, Cardiac - ultrastructure Nuclear Proteins - analysis Peptidyl-Dipeptidase A - analysis Ribonucleoproteins Serine-Arginine Splicing Factors Transforming Growth Factor beta - analysis Transforming Growth Factor beta1 Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Pressure
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Beschreibung
Zusammenfassung:	The progression of compensated hypertrophy to heart failure (HF) is still debated. We investigated patients with isolated valvular aortic stenosis and differing degrees of left ventricular (LV) systolic dysfunction to test the hypothesis that structural remodeling, as well as cell death, contributes to the transition to HF. Structural alterations were studied in LV myectomies from 3 groups of patients (group 1: ejection fraction [EF] >50%, n=12; group 2: EF 30% to 50%, n=12; group 3: EF
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.0000051865.66123.B7