Long-term neurochemical and behavioral effects induced by acute chlorpyrifos treatment

A single dose of the organophosphate insecticide O, O′-diethyl- O-3,5,6-trichloro-2-pyridylphosphorothioate [chlorpyrifos (CPF), 279 mg/kg, SC] caused extensive inhibition of cortical and striatal cholinesterase (ChE) activity in adult rats at 2 (94–96%), 4 (83–84%), and 6(58–60%) weeks after treatm...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-06, Vol.42 (2), p.251-256
Hauptverfasser:	Pope, C.N., Chakraborti, T.K., Chapman, M.L., Farrar, J.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Biological and medical sciences Brain Chemistry - drug effects Cerebral Cortex - drug effects Cerebral Cortex - enzymology Chlorpyrifos Chlorpyrifos - pharmacology Cholinesterase inhibition Cholinesterases - metabolism Corpus Striatum - drug effects Corpus Striatum - enzymology Male Medical sciences Motor activity Motor Activity - drug effects Muscarinic receptors Organophosphate Pesticides, fertilizers and other agrochemicals toxicology Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects Scopolamine Scopolamine - pharmacology Toxicology
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