Long-term neurochemical and behavioral effects induced by acute chlorpyrifos treatment

A single dose of the organophosphate insecticide O, O′-diethyl- O-3,5,6-trichloro-2-pyridylphosphorothioate [chlorpyrifos (CPF), 279 mg/kg, SC] caused extensive inhibition of cortical and striatal cholinesterase (ChE) activity in adult rats at 2 (94–96%), 4 (83–84%), and 6(58–60%) weeks after treatm...

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Veröffentlicht in:Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-06, Vol.42 (2), p.251-256
Hauptverfasser: Pope, C.N., Chakraborti, T.K., Chapman, M.L., Farrar, J.D.
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Sprache:eng
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Zusammenfassung:A single dose of the organophosphate insecticide O, O′-diethyl- O-3,5,6-trichloro-2-pyridylphosphorothioate [chlorpyrifos (CPF), 279 mg/kg, SC] caused extensive inhibition of cortical and striatal cholinesterase (ChE) activity in adult rats at 2 (94–96%), 4 (83–84%), and 6(58–60%) weeks after treatment. These persistent changes in ChE activity were concomitant with reductions in muscarinic receptor binding sites in cortex (34, 33, and 18% reduction in B max) and striatum (48, 40, and 23% reduction in B max) at 2, 4, and 6 weeks after exposure. Neither ChE activities nor muscarinic receptor densities were different from control levels at 12 weeks after exposure. CPF treatment caused a reduction in locomotor activity for the first 2 days after treatment, after which basal activity levels were not different from controls. CPF-treated rats showed higher activity relative to controls, however, following challenge with scopolamine (1 mg/kg, IP) at 2, 4, 6, 8, and 12 weeks after treatment. These data indicate that acute exposure to CPF in adult rats can cause long-term neurobehavioral changes that may persist following the recovery of neurochemical parameters associated with exposure and tolerance to cholinesterase hibitors.
ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(92)90523-I