Mitral Annular Calcification and the Risk of Stroke in an Elderly Cohort

Mitral Annular Calcification and the Risk of Stroke in an Elderly Cohort

CALCIFICATION of the mitral annulus is a noninflammatory chronic degenerative process of the fibrous support structure of the mitral valve. 1 2 3 4 Mitral annular calcification (MAC) occurs more commonly in women and the elderly. 5 It has also been reported to be associated with elevated systolic bl...

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Veröffentlicht in:The New England journal of medicine 1992-08, Vol.327 (6), p.374-379
Hauptverfasser: Benjamin, Emelia J, Plehn, Jonathan F, D'Agostino, Ralph B, Belanger, Albert J, Comai, Kathy, Fuller, Deborah L, Wolf, Philip A, Levy, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Biological and medical sciences
Calcinosis - complications
Calcinosis - diagnostic imaging
Cardiology. Vascular system
Cerebrovascular Disorders - etiology
Cohort Studies
Coronary Disease - complications
Echocardiography
Endocardial and cardiac valvular diseases
Female
Follow-Up Studies
Heart
Heart Valve Diseases - complications
Heart Valve Diseases - diagnostic imaging
Humans
Longitudinal Studies
Male
Medical research
Medical sciences
Middle Aged
Mitral Valve - pathology
Multivariate Analysis
Older people
Proportional Hazards Models
Risk
Stroke
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Zusammenfassung:CALCIFICATION of the mitral annulus is a noninflammatory chronic degenerative process of the fibrous support structure of the mitral valve. 1 2 3 4 Mitral annular calcification (MAC) occurs more commonly in women and the elderly. 5 It has also been reported to be associated with elevated systolic blood pressure, obesity, and atrial fibrillation. 5 The putative sequelae of MAC include mitral stenosis, 3 mitral regurgitation, 3 , 4 , 6 infective endocarditis, 4 , 7 atrial arrhythmias, 3 , 8 heart block, 4 , 6 congestive heart failure, 4 , 6 , 8 and stroke. Since the account of a stroke in a patient with MAC by Rytand and Lipsitch in 1946, 6 numerous hospital-based case reports, 9 10 11 case series, 3 , 4 , 7 , 12 13 14 15 16 17 18 19 case–control studies, 20 21 22 and cohort studies 8 , 23 have suggested . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199208063270602