Familial Alzheimer's mutation: mRNA secondary structure revisited
It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on compari...
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| Veröffentlicht in: | Neurobiology of aging 1992-05, Vol.13 (3), p.449-451 |
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| container_title | Neurobiology of aging |
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| creator | Brosius, Jürgen Konings, Danielle |
| description | It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on comparison with other mammalian APP sequences does not support this possibility. |
| doi_str_mv | 10.1016/0197-4580(92)90120-M |
| format | Article |
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Prion diseases</subject><subject>Hereditary Alzheimer's disease</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Messenger RNA secondary structure</subject><subject>Molecular Sequence Data</subject><subject>Mutation - genetics</subject><subject>Neurology</subject><subject>Nucleic Acid Conformation</subject><subject>Point mutations</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMo4zj6Bgp9EJdDa9JJOmkPwiBu4AKi55BOKhjpZUy6BX16exb0pqc61Pf_VH0I7RJ8QjDJTzEpRMq4xEdFdlxgkuH0fg2NCecyJawQ62j8g2yirRjfMMaCiXyERiTPuBB8jKZXuvaV11Uyrb5ewdcQDmNS953ufNucJfXTwzSJYNrG6vCZxC70pusDJAE-fPQd2G204XQVYWc1J-jl6vL54ia9e7y-vZjepSaTpEtzSaWhjmOiOdMud7QsLRGGO-YEZE7aEiQzQjtLBRYG25IzTCixvCyZo3SCDpa9s9C-9xA7VftooKp0A20flaCYyUyyf0GS84JgyQeQLUET2hgDODULvh7eVASruWI196fm_lSRqYVidT_E9lb9fVmD_Q0tnQ77_dVeR6MrF3RjfPzBOKWFXGDnSwwGaR8egorGQ2PA-gCmU7b1f9_xDXbql48</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>Brosius, Jürgen</creator><creator>Konings, Danielle</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Familial Alzheimer's mutation: mRNA secondary structure revisited</title><author>Brosius, Jürgen ; Konings, Danielle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-6838c3f501a54af6f3bbd17c5f4f7e2f8dbe84c7afd3707c0db540131d5bb4f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Alzheimer Disease - genetics</topic><topic>Amyloid beta-Protein Precursor - genetics</topic><topic>Amyloid precursor protein</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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| ispartof | Neurobiology of aging, 1992-05, Vol.13 (3), p.449-451 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alzheimer Disease - genetics Amyloid beta-Protein Precursor - genetics Amyloid precursor protein Animals Base Sequence Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Hereditary Alzheimer's disease Humans Medical sciences Messenger RNA secondary structure Molecular Sequence Data Mutation - genetics Neurology Nucleic Acid Conformation Point mutations RNA, Messenger - chemistry RNA, Messenger - genetics |
| title | Familial Alzheimer's mutation: mRNA secondary structure revisited |
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