Familial Alzheimer's mutation: mRNA secondary structure revisited

It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on compari...

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Veröffentlicht in:	Neurobiology of aging 1992-05, Vol.13 (3), p.449-451
Hauptverfasser:	Brosius, Jürgen, Konings, Danielle
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Amyloid beta-Protein Precursor - genetics Amyloid precursor protein Animals Base Sequence Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Hereditary Alzheimer's disease Humans Medical sciences Messenger RNA secondary structure Molecular Sequence Data Mutation - genetics Neurology Nucleic Acid Conformation Point mutations RNA, Messenger - chemistry RNA, Messenger - genetics
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Zusammenfassung:	It has been suggested that the mutation at position 717 of the amyloid precursor protein (APP), found in several cases of familial Alzheimer's disease, affects the secondary structure of the corresponding messenger RNA and the rate of its translation (10). Phylogenetic analysis based on comparison with other mammalian APP sequences does not support this possibility.
ISSN:	0197-4580 1558-1497
DOI:	10.1016/0197-4580(92)90120-M