The prognostic value of DNA content measured by image cytometry in soft tissue sarcomas

Nuclear DNA content in soft tissue sarcoma was determined by image cytometry using archival, paraffin embedded material. In a retrospective study 138 specimens of 81 patients have been analysed. The ploidy level was correlated to clinical outcome regarding tumor volume and histological grading, the...

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Veröffentlicht in:	Annals of oncology 1992-04, Vol.3 (suppl-2), p.S89-S92
Hauptverfasser:	Pape, H., Pöttgen, Ch, Ploem, J. S., Van Driel-Kulker, A. M. J., Wurm, R., Schmitt, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Child, Preschool Dermatology DNA content DNA, Neoplasm - analysis Female Humans image cytometry Image Processing, Computer-Assisted Infant Male Medical sciences Middle Aged Paraffin Embedding Ploidies Prognosis Retrospective Studies Sarcoma - genetics Soft Tissue Neoplasms - genetics soft tissue sarcoma Television Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	Nuclear DNA content in soft tissue sarcoma was determined by image cytometry using archival, paraffin embedded material. In a retrospective study 138 specimens of 81 patients have been analysed. The ploidy level was correlated to clinical outcome regarding tumor volume and histological grading, the most important prognostic parameters. Ploidy has a significant prognostic value and correlates well with histological grading (p=0.01). Tumour volume was found to be an independent prognostic factor (p=>0.1) [x2 test]. The DNA content of the primary tumour and of multiple local recurrences remained similar.
ISSN:	0923-7534 1569-8041
DOI:	10.1093/annonc/3.suppl_2.S89