Low-Positive Anti-Hepatitis C Virus Enzyme Immunoassay Results: An Important Predictor of Low Likelihood of Hepatitis C Infection

Tests for hepatitis C antibodies (anti-HCV enzyme immunoassays) are usually described as positive or negative. Several studies, mainly in blood donors, have found that specimens with low signal/cutoff (S/C) ratios are commonly negative when tested with a recombinant immunoblot assay (RIBA) or for HC...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2003-03, Vol.49 (3), p.479-486
Hauptverfasser:	Dufour, D. Robert, Talastas, Mageli, Fernandez, Maria D.A, Harris, Barbara, Strader, Doris B, Seeff, Leonard B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies Antigens Biological and medical sciences Biomarkers - blood Blood & organ donations Drug abuse Drug use Enzymes False Positive Reactions Hepatitis Hepatitis C Hepatitis C - diagnosis Hepatitis C Antibodies - blood Humans Immunoassay Immunoassays Immunoblotting - methods Immunoenzyme Techniques Infections Investigative techniques, diagnostic techniques (general aspects) Laboratories Medical sciences Middle Aged Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Patients Proteins Questionnaires Retrospective Studies Risk Factors RNA, Viral - blood Serologic Tests Veterans
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Zusammenfassung:	Tests for hepatitis C antibodies (anti-HCV enzyme immunoassays) are usually described as positive or negative. Several studies, mainly in blood donors, have found that specimens with low signal/cutoff (S/C) ratios are commonly negative when tested with a recombinant immunoblot assay (RIBA) or for HCV RNA. We retrospectively reviewed 17 418 consecutive anti-HCV results from a screening program for high-risk veterans; 2986 (17.1%) samples were anti-HCV-positive, and 490 (16.4%) had S/C ratios
ISSN:	0009-9147 1530-8561
DOI:	10.1373/49.3.479