Effect of oral cyclosporin A in children with Staphylococcus aureus-colonized vs. S. aureus-infected severe atopic dermatitis

Atopic dermatitis (AD) is frequently associated with skin colonization or infection with Staphylococcus aureus strains producing exotoxins. The aim of this investigation was to evaluate the effect of oral cyclosporin A (CsA) on disease severity and bacterial counts in colonized and infected patients...

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Veröffentlicht in:Pediatric allergy and immunology 2003-02, Vol.14 (1), p.55-59
Hauptverfasser: Bunikowski, Rita, Mielke, Martin, Bräutigam, Matthias, Renz, Harald, Wahn, Ulrich
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Sprache:eng
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Zusammenfassung:Atopic dermatitis (AD) is frequently associated with skin colonization or infection with Staphylococcus aureus strains producing exotoxins. The aim of this investigation was to evaluate the effect of oral cyclosporin A (CsA) on disease severity and bacterial counts in colonized and infected patients. Eleven children with severe AD (SCORAD index >50, mean objective SCORAD score >40) were treated for 8 weeks with 2.5–5 mg/kg CsA. In five patients, the skin was only colonized with S. aureus whereas the remaining six patients presented clinically relevant suppurative S. aureus skin infections characterized by small pustules, crustings, pus and increased pruritus in the presence of S. aureus as determined by contact sampling and culture which regularly resulted in the indication for antibiotic treatment. Clinical and microbiological investigations were performed before and after CsA therapy. Clinical signs and symptoms of AD improved in all patients with a reduction in mean SCORAD index from 74 to 29 (p 
ISSN:0905-6157
1399-3038
DOI:10.1034/j.1399-3038.2003.02105.x