The DDT method: An alternative to the use of radiolabelled microspheres for the determination of regional blood flows in the rat

The DDT method: An alternative to the use of radiolabelled microspheres for the determination of regional blood flows in the rat

Intravenous administration of the 14C-radiolabelled insecticide DDT — 1,1,1-trichloro-2,2-bis-( p-chlorophenyl)ethane — can be used for the estimation of regional blood flows in small rodents. A mathematical model is presented which enables the conversion of relative into absolute blood flows.

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Veröffentlicht in:Medical hypotheses 1992-04, Vol.37 (4), p.268-270
Hauptverfasser: ARGILES, J. M, ZEGRI, A, LOPEZ-SORIANO, F. J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
DDT - blood
DDT - pharmacokinetics
Evaluation Studies as Topic
Hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Mice
Microspheres
Models, Biological
Rats
Regional Blood Flow
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Zusammenfassung:Intravenous administration of the 14C-radiolabelled insecticide DDT — 1,1,1-trichloro-2,2-bis-( p-chlorophenyl)ethane — can be used for the estimation of regional blood flows in small rodents. A mathematical model is presented which enables the conversion of relative into absolute blood flows.
ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(92)90199-M