Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides

The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer’s disease (AD) brain is unknown. In this study we report that amyloid β-peptides (Aβ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both n...

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Veröffentlicht in:	Brain research 2003-03, Vol.965 (1), p.283-286
Hauptverfasser:	Sáez-Valero, Javier, Fodero, Lisa R, White, Anthony R, Barrow, Colin J, Small, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - biosynthesis Alzheimer’s disease Amyloid beta-Peptides - pharmacology Amyloid peptide Animals Astrocyte Astrocytes - drug effects Astrocytes - enzymology Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Cerebral Cortex - physiology Embryo, Mammalian Mice Mice, Inbred C57BL Neuron Neurons - drug effects Neurons - enzymology Peptide Fragments - pharmacology
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Zusammenfassung:	The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer’s disease (AD) brain is unknown. In this study we report that amyloid β-peptides (Aβ) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(02)04159-8