A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A
The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-...
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Veröffentlicht in: | Journal of antibiotics 1992/05/25, Vol.45(5), pp.692-697 |
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container_title | Journal of antibiotics |
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creator | SASAKI, TORU TAKAGI, MASAYUKI YAGUCHI, TAKASI MIYADOH, SHINJI OKADA, TADAAKI KOYAMA, MASAO |
description | The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies. |
doi_str_mv | 10.7164/antibiotics.45.692 |
format | Article |
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It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.692</identifier><identifier>PMID: 1624372</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Anthelmintics - chemistry ; Anthelmintics - isolation & purification ; Anthelmintics - pharmacology ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Applied microbiology ; Ascaridia - drug effects ; Ascaridia galli ; Biological and medical sciences ; Chickens ; Depsipeptides ; Fundamental and applied biological sciences. Psychology ; Microbiology ; Mitosporic Fungi - chemistry ; Mycelia sterilia ; Peptides, Cyclic - chemistry ; Peptides, Cyclic - isolation & purification ; Peptides, Cyclic - pharmacology</subject><ispartof>The Journal of Antibiotics, 1992/05/25, Vol.45(5), pp.692-697</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c637t-f3b2ef621876f6a21255f447e87ee35ab43bf276b3e0726c9fc0b31d8e27edc33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4359983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1624372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SASAKI, TORU</creatorcontrib><creatorcontrib>TAKAGI, MASAYUKI</creatorcontrib><creatorcontrib>YAGUCHI, TAKASI</creatorcontrib><creatorcontrib>MIYADOH, SHINJI</creatorcontrib><creatorcontrib>OKADA, TADAAKI</creatorcontrib><creatorcontrib>KOYAMA, MASAO</creatorcontrib><title>A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.</description><subject>Animals</subject><subject>Anthelmintics - chemistry</subject><subject>Anthelmintics - isolation & purification</subject><subject>Anthelmintics - pharmacology</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Applied microbiology</subject><subject>Ascaridia - drug effects</subject><subject>Ascaridia galli</subject><subject>Biological and medical sciences</subject><subject>Chickens</subject><subject>Depsipeptides</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Microbiology</subject><subject>Mitosporic Fungi - chemistry</subject><subject>Mycelia sterilia</subject><subject>Peptides, Cyclic - chemistry</subject><subject>Peptides, Cyclic - isolation & purification</subject><subject>Peptides, Cyclic - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwkAUhSdGg4i-gIkJC-PK4vzPdElKkUYEEjHG1WQ6zGhNabFTFr69JSXIzs29i_Pde04OANcIDgTi9EEXdZZmZZ0ZP6BswEN8ArpIShQgysNT0IUQo0BKDM_BhfdfEBJBhOyADuKYEoG7IBj2Z_FbfzhbTuLpczJbJlE_eo-m81G8eEkW8WKZjOL7_mKMIMbDS3DmdO7t1X73wOs4XkaTYDp_TKLhNDCciDpwJMXWcYyk4I5rjDBjjlJhpbCWMJ1SkjoseEosFJib0BmYErSSFgu7MoT0wF37d1OV31vra7XOvLF5rgtbbr0SBFJC6f8g4gwKImED4hY0Vel9ZZ3aVNlaVz8KQbUrUx2VqShTTZnN0c3--zZd29XfSdteo9_ude2Nzl2lC5P5A0YJC0O5C_nUYl--1h_2oOuqMcvtsTMKudy5s3Y0IQ6U-dSVsgX5BWlllSs</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>SASAKI, TORU</creator><creator>TAKAGI, MASAYUKI</creator><creator>YAGUCHI, TAKASI</creator><creator>MIYADOH, SHINJI</creator><creator>OKADA, TADAAKI</creator><creator>KOYAMA, MASAO</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A</title><author>SASAKI, TORU ; TAKAGI, MASAYUKI ; YAGUCHI, TAKASI ; MIYADOH, SHINJI ; OKADA, TADAAKI ; KOYAMA, MASAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c637t-f3b2ef621876f6a21255f447e87ee35ab43bf276b3e0726c9fc0b31d8e27edc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Anthelmintics - chemistry</topic><topic>Anthelmintics - isolation & purification</topic><topic>Anthelmintics - pharmacology</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Applied microbiology</topic><topic>Ascaridia - drug effects</topic><topic>Ascaridia galli</topic><topic>Biological and medical sciences</topic><topic>Chickens</topic><topic>Depsipeptides</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Microbiology</topic><topic>Mitosporic Fungi - chemistry</topic><topic>Mycelia sterilia</topic><topic>Peptides, Cyclic - chemistry</topic><topic>Peptides, Cyclic - isolation & purification</topic><topic>Peptides, Cyclic - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SASAKI, TORU</creatorcontrib><creatorcontrib>TAKAGI, MASAYUKI</creatorcontrib><creatorcontrib>YAGUCHI, TAKASI</creatorcontrib><creatorcontrib>MIYADOH, SHINJI</creatorcontrib><creatorcontrib>OKADA, TADAAKI</creatorcontrib><creatorcontrib>KOYAMA, MASAO</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SASAKI, TORU</au><au>TAKAGI, MASAYUKI</au><au>YAGUCHI, TAKASI</au><au>MIYADOH, SHINJI</au><au>OKADA, TADAAKI</au><au>KOYAMA, MASAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>5</issue><spage>692</spage><epage>697</epage><pages>692-697</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>1624372</pmid><doi>10.7164/antibiotics.45.692</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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source | J-STAGE Free; MEDLINE |
subjects | Animals Anthelmintics - chemistry Anthelmintics - isolation & purification Anthelmintics - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascaridia - drug effects Ascaridia galli Biological and medical sciences Chickens Depsipeptides Fundamental and applied biological sciences. Psychology Microbiology Mitosporic Fungi - chemistry Mycelia sterilia Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology |
title | A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A |
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