A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A

The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-...

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Veröffentlicht in:Journal of antibiotics 1992/05/25, Vol.45(5), pp.692-697
Hauptverfasser: SASAKI, TORU, TAKAGI, MASAYUKI, YAGUCHI, TAKASI, MIYADOH, SHINJI, OKADA, TADAAKI, KOYAMA, MASAO
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container_end_page 697
container_issue 5
container_start_page 692
container_title Journal of antibiotics
container_volume 45
creator SASAKI, TORU
TAKAGI, MASAYUKI
YAGUCHI, TAKASI
MIYADOH, SHINJI
OKADA, TADAAKI
KOYAMA, MASAO
description The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.
doi_str_mv 10.7164/antibiotics.45.692
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Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>5</issue><spage>692</spage><epage>697</epage><pages>692-697</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>1624372</pmid><doi>10.7164/antibiotics.45.692</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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ispartof The Journal of Antibiotics, 1992/05/25, Vol.45(5), pp.692-697
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subjects Animals
Anthelmintics - chemistry
Anthelmintics - isolation & purification
Anthelmintics - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Ascaridia - drug effects
Ascaridia galli
Biological and medical sciences
Chickens
Depsipeptides
Fundamental and applied biological sciences. Psychology
Microbiology
Mitosporic Fungi - chemistry
Mycelia sterilia
Peptides, Cyclic - chemistry
Peptides, Cyclic - isolation & purification
Peptides, Cyclic - pharmacology
title A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A
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