A NEW ANTHELMINTIC CYCLODEPSIPEPTIDE, PF1022A

The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-...

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Veröffentlicht in:	Journal of antibiotics 1992/05/25, Vol.45(5), pp.692-697
Hauptverfasser:	SASAKI, TORU, TAKAGI, MASAYUKI, YAGUCHI, TAKASI, MIYADOH, SHINJI, OKADA, TADAAKI, KOYAMA, MASAO
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthelmintics - chemistry Anthelmintics - isolation & purification Anthelmintics - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Ascaridia - drug effects Ascaridia galli Biological and medical sciences Chickens Depsipeptides Fundamental and applied biological sciences. Psychology Microbiology Mitosporic Fungi - chemistry Mycelia sterilia Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology
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Beschreibung
Zusammenfassung:	The novel anthelmintic cyclodepsipeptide PF1022A was isolated from cultured mycelia of Mycelia Sterilia PF1022 (PERM BP-2671). It showed strong anthelmintic activities against Ascaridia galli in chickens. The structure of PF1022A was determined to be cyclo(D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl-D-lactyl-L-N-methylleucyl-D-3-phenyllactyl-L-N-methylleucyl) by spectroscopic analyses and chemical studies.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.45.692