Recurrence of myomas after myomectomy in women pretreated with leuprolide acetate depot or placebo

The recurrence of myomas and myoma-related symptoms was evaluated in women participating in a randomized, double-blind, P-controlled study of the efficacy of LA depot before myomectomy. After 27 to 38 months of follow-up, the recurrence of myomas was found to be greater when at least four myomas wer...

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Veröffentlicht in:	Fertility and sterility 1992-07, Vol.58 (1), p.205-208
Hauptverfasser:	Friedman, Andrew J., Daly, Margaret, Juneau-Norcross, Fine, Calliope, Rein, Mitchell S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Combined Modality Therapy Delayed-Action Preparations Female Follow-Up Studies gonadotropin-releasing hormone agonists Hormones. Endocrine system Humans Incidence leuprolide Leuprolide - administration & dosage Leuprolide - therapeutic use Medical sciences Myoma Myoma - drug therapy Myoma - epidemiology Myoma - surgery myomectomy Pharmacology. Drug treatments placebo Recurrence Uterine Neoplasms - drug therapy Uterine Neoplasms - epidemiology Uterine Neoplasms - surgery
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Zusammenfassung:	The recurrence of myomas and myoma-related symptoms was evaluated in women participating in a randomized, double-blind, P-controlled study of the efficacy of LA depot before myomectomy. After 27 to 38 months of follow-up, the recurrence of myomas was found to be greater when at least four myomas were resected. Myoma recurrence was not associated with pretreatment or preoperative uterine volume, resected myoma mass, or preoperative medical therapy.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/S0015-0282(16)55164-4