The Induction of Apoptosis by Local Anesthetics: A Comparison Between Lidocaine and Ropivacaine

This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.

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Bibliographische Detailangaben
Veröffentlicht in:	Anesthesia and analgesia 2003-03, Vol.96 (3), p.755-756
Hauptverfasser:	Boselli, Emmanuel, Duflo, Frédéric, Debon, Richard, Allaouchiche, Bernard, Chassard, Dominique, Thomas, Luc, Portoukalian, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Anesthetics, Local - pharmacology Apoptosis - drug effects Biological and medical sciences Cell Survival - drug effects Drug toxicity and drugs side effects treatment Flow Cytometry Humans Jurkat Cells Lidocaine - pharmacology Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Phosphatidylserines - metabolism Ropivacaine
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Beschreibung
Zusammenfassung:	This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.
ISSN:	0003-2999 1526-7598
DOI:	10.1213/01.ANE.0000047201.85815.9D