A High Repetition Rate (1 kHz) Microcrystal Laser for High Throughput Atmospheric Pressure MALDI-Quadrupole-Time-of-Flight Mass Spectrometry

A High Repetition Rate (1 kHz) Microcrystal Laser for High Throughput Atmospheric Pressure MALDI-Quadrupole-Time-of-Flight Mass Spectrometry

Sample throughput has been increased in many areas of proteomics, but the last significant advance in lasers used for matrix-assisted laser desorption/ionization (MALDI) was the introduction of cartridge-type N2 lasers (337 nm, 4-ns pulse widths, 1−30-Hz repetition rates) more than a decade ago. Thi...

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Veröffentlicht in:Analytical chemistry (Washington) 2003-02, Vol.75 (3), p.648-654
Hauptverfasser: McLean, John A, Russell, William K, Russell, David H
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Chemistry
Exact sciences and technology
Spectrometric and optical methods
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Zusammenfassung:Sample throughput has been increased in many areas of proteomics, but the last significant advance in lasers used for matrix-assisted laser desorption/ionization (MALDI) was the introduction of cartridge-type N2 lasers (337 nm, 4-ns pulse widths, 1−30-Hz repetition rates) more than a decade ago. This report describes the application of a 1-kHz repetition rate Nd:YAG laser (355 nm,
ISSN:0003-2700
1520-6882
DOI:10.1021/ac026029y