Pharmacokinetics of diphemanil methylsulphate in healthy subjects

Pharmacokinetics of diphemanil methylsulphate in healthy subjects

The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:European journal of clinical pharmacology 1992-06, Vol.42 (6), p.689-691
Hauptverfasser: Vidal, A M, Rey, E, Pons, G, Pello, J Y, d'Athis, P, Olive, G
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Adult
Humans
Male
Metabolic Clearance Rate
Piperidines - administration & dosage
Piperidines - pharmacokinetics
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00265939