Mucosal high apoptotic activity and low p21WAF1/CIP1 expression and submucosal low proliferative activity in superficially spreading early gastric cancers: Comparison with the penetrating growth type

Mucosal high apoptotic activity and low p21WAF1/CIP1 expression and submucosal low proliferative activity in superficially spreading early gastric cancers: Comparison with the penetrating growth type

In order to investigate cell kinetics and cell cycle regulator protein expression with reference to the growth pattern of early gastric carcinomas (EGCs), we evaluated a total of 240 EGCs with submucosal invasion clinicopathologically and 106 submucosal invasive lesions immunohistochemically. The in...

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Veröffentlicht in:Pathology international 2003-02, Vol.53 (2), p.81-89
Hauptverfasser: Ichinoe, Masaaki, Mitomi, Hiroyuki, Kikuchi, Shiro, Tanabe, Satoshi, Akino, Fumiyuki, Okayasu, Isao
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - classification
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Apoptosis
Biomarkers, Tumor - metabolism
Cell Count
cell kinetics
Cyclin-Dependent Kinase Inhibitor p21
Cyclins - metabolism
DNA - biosynthesis
DNA, Neoplasm - analysis
early gastric cancer
Female
Gastric Mucosa - pathology
growth pattern
Humans
Immunoenzyme Techniques
immunohistochemistry
Ki-67 Antigen - metabolism
Kinetics
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Invasiveness
p21WAF1/CIP1
penetrating growth type
Stomach Neoplasms - classification
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
superficially spreading type
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Zusammenfassung:In order to investigate cell kinetics and cell cycle regulator protein expression with reference to the growth pattern of early gastric carcinomas (EGCs), we evaluated a total of 240 EGCs with submucosal invasion clinicopathologically and 106 submucosal invasive lesions immunohistochemically. The incidence of lymph node metastasis was relatively high (36.4%) in the superficially spreading growth (SUP) type tumors whereas the penetrating growth (PEN) type had a low incidence (5.7%, P
ISSN:1320-5463
1440-1827
DOI:10.1046/j.1440-1827.2003.01438.x