A New Principle in Combinatorial Asymmetric Transition-Metal Catalysis: Mixtures of Chiral Monodentate P Ligands

A New Principle in Combinatorial Asymmetric Transition-Metal Catalysis: Mixtures of Chiral Monodentate P Ligands

The right mix!: Surprisingly, the use of the mixture of two different chiral monodentate phosphorus ligands (e.g., a phosphonite/phosphite combination; see schematic representation; cod=1,5‐cyclooctadiene) in Rh‐catalyzed olefin hydrogenation leads to significantly higher enantioselectivities than i...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-02, Vol.42 (7), p.790-793
Hauptverfasser: Reetz, Manfred T., Sell, Thorsten, Meiswinkel, Andreas, Mehler, Gerlinde
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
combinatorial chemistry
hydrogenation
phosphorus
rhodium
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Zusammenfassung:The right mix!: Surprisingly, the use of the mixture of two different chiral monodentate phosphorus ligands (e.g., a phosphonite/phosphite combination; see schematic representation; cod=1,5‐cyclooctadiene) in Rh‐catalyzed olefin hydrogenation leads to significantly higher enantioselectivities than in the case of the pure ligands themselves.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200390209