A Highly Practical and Enantioselective Reagent for the Allylation of Aldehydes

A Highly Practical and Enantioselective Reagent for the Allylation of Aldehydes

Strain at silicon is the key to success of reagent 1 since this strain, which is induced by the diazasilacyclopentane ring, determines its reactivity. This practical and general new reagent for the highly enantioselective allylation of aldehydes is easily prepared as an air‐stable solid and may be s...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-02, Vol.42 (8), p.946-948
Hauptverfasser: Kubota, Katsumi, Leighton, James L.
Format: Artikel
Sprache:eng
Schlagworte:
aldehydes
allylation
asymmetric synthesis
chiral auxiliaries
homoallylic alcohols
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Zusammenfassung:Strain at silicon is the key to success of reagent 1 since this strain, which is induced by the diazasilacyclopentane ring, determines its reactivity. This practical and general new reagent for the highly enantioselective allylation of aldehydes is easily prepared as an air‐stable solid and may be stored without significant decomposition.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200390252