Effects of Natural Polysaccharide Addition on Drug Release from Calcium-Induced Alginate Gel Beads

Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was qui...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2003, Vol.51(2), pp.218-220
Hauptverfasser:	Murata, Yoshifumi, Tsumoto, Kumiko, Kofuji, Kyoko, Kawashima, Susumu
Format:	Artikel
Sprache:	eng
Schlagworte:	alginate gel bead Alginates - chemical synthesis Alginates - pharmacokinetics alginic acid Biological and medical sciences Calcium - chemistry Calcium - pharmacokinetics Chemistry, Pharmaceutical chitin Gels General pharmacology Glucuronic Acid Hexuronic Acids hydrocortisone Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polysaccharides - chemical synthesis Polysaccharides - pharmacokinetics
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Beschreibung
Zusammenfassung:	Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.51.218