Cell surface CD43 determination improves diagnostic precision in late B‐cell diseases
Panels of immunological markers are useful in refining diagnosis in view of certain variability between B‐cell leukaemias. A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, C...
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Veröffentlicht in: | British journal of haematology 2003-02, Vol.120 (3), p.496-499 |
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creator | Jung, Georges Eisenmann, Jean‐Claude Thiébault, Sylvie Hénon, Philippe |
description | Panels of immunological markers are useful in refining diagnosis in view of certain variability between B‐cell leukaemias. A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, CD23, CD79b, FMC7, CD22 and surface immunoglobulin to differentiate chronic lymphoid leukaemia (CLL) from lymphoma (non‐CLL). CD43 was highly effective (P |
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A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, CD23, CD79b, FMC7, CD22 and surface immunoglobulin to differentiate chronic lymphoid leukaemia (CLL) from lymphoma (non‐CLL). CD43 was highly effective (P < 0·00001) and its inclusion in the panels improved the accuracy of discrimination in a ‘control’ sample of 74 B leukaemias to 98·6%. Inclusion of CD43 facilitates the diagnosis of B‐lymphoproliferative disorders and improves their classification.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2003.04071.x</identifier><identifier>PMID: 12580968</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Antigens, CD ; Antigens, Neoplasm - analysis ; B-Lymphocytes - immunology ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; CD43 ; Diagnosis, Differential ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; immunophenotype ; Immunophenotyping ; Leukemia, B-Cell - diagnosis ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukosialin ; Lymphoma, B-Cell - diagnosis ; lymphoproliferative disorder ; Medical sciences ; Multivariate Analysis ; Neoplasm Proteins - analysis ; Sialoglycoproteins - analysis</subject><ispartof>British journal of haematology, 2003-02, Vol.120 (3), p.496-499</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. 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A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, CD23, CD79b, FMC7, CD22 and surface immunoglobulin to differentiate chronic lymphoid leukaemia (CLL) from lymphoma (non‐CLL). CD43 was highly effective (P < 0·00001) and its inclusion in the panels improved the accuracy of discrimination in a ‘control’ sample of 74 B leukaemias to 98·6%. Inclusion of CD43 facilitates the diagnosis of B‐lymphoproliferative disorders and improves their classification.</description><subject>Antigens, CD</subject><subject>Antigens, Neoplasm - analysis</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>CD43</subject><subject>Diagnosis, Differential</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>immunophenotype</subject><subject>Immunophenotyping</subject><subject>Leukemia, B-Cell - diagnosis</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukosialin</subject><subject>Lymphoma, B-Cell - diagnosis</subject><subject>lymphoproliferative disorder</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Proteins - analysis</subject><subject>Sialoglycoproteins - analysis</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu1DAUhq0KRKeFV6gsJLpLOL4kthddtEOhoEpsQCwt23GQR7lM7aSXHY_AM_IkOJ0Rlbpi5WOd7z_69SGECZQEeP1-UxJWVwUlnJQUgJXAQZDy_gCt_i1eoBUAiCIH5CE6SmkDQBhU5BU6JLSSoGq5Qj_WvutwmmNrnMfrD5zhxk8-9mEwUxgHHPptHG99wk0wP4cxTcHhbfQupMftgDszeXzx59dvt1xqQvIm-fQavWxNl_yb_XuMvn-8_La-Kq6_fvq8Pr8uHBeUFMzWlLfG2JbZ3NwZoYTwlEurBFWS1PlDQSmnqLUtV2ApN2BbJxm1gjTsGJ3u7uaWN7NPk-5DWpqYwY9z0oIBUZXgGXz7DNyMcxxyN02UrKXkqsqQ3EEujilF3-ptDL2JD5qAXszrjV4E60WwXszrR_P6PkdP9vdn2_vmKbhXnYF3e8AkZ7o2miFLfOJ4xQhUC3e24-5C5x_-u4C--HK1TOwvvW6eKQ</recordid><startdate>200302</startdate><enddate>200302</enddate><creator>Jung, Georges</creator><creator>Eisenmann, Jean‐Claude</creator><creator>Thiébault, Sylvie</creator><creator>Hénon, Philippe</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200302</creationdate><title>Cell surface CD43 determination improves diagnostic precision in late B‐cell diseases</title><author>Jung, Georges ; Eisenmann, Jean‐Claude ; Thiébault, Sylvie ; Hénon, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4721-3b624faabf3b136ca7977e248b97298167e22099c92bbf490b24a0bfc832b71d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antigens, CD</topic><topic>Antigens, Neoplasm - analysis</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>CD43</topic><topic>Diagnosis, Differential</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>immunophenotype</topic><topic>Immunophenotyping</topic><topic>Leukemia, B-Cell - diagnosis</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukosialin</topic><topic>Lymphoma, B-Cell - diagnosis</topic><topic>lymphoproliferative disorder</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Proteins - analysis</topic><topic>Sialoglycoproteins - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Georges</creatorcontrib><creatorcontrib>Eisenmann, Jean‐Claude</creatorcontrib><creatorcontrib>Thiébault, Sylvie</creatorcontrib><creatorcontrib>Hénon, Philippe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Georges</au><au>Eisenmann, Jean‐Claude</au><au>Thiébault, Sylvie</au><au>Hénon, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell surface CD43 determination improves diagnostic precision in late B‐cell diseases</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2003-02</date><risdate>2003</risdate><volume>120</volume><issue>3</issue><spage>496</spage><epage>499</epage><pages>496-499</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Panels of immunological markers are useful in refining diagnosis in view of certain variability between B‐cell leukaemias. A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, CD23, CD79b, FMC7, CD22 and surface immunoglobulin to differentiate chronic lymphoid leukaemia (CLL) from lymphoma (non‐CLL). CD43 was highly effective (P < 0·00001) and its inclusion in the panels improved the accuracy of discrimination in a ‘control’ sample of 74 B leukaemias to 98·6%. Inclusion of CD43 facilitates the diagnosis of B‐lymphoproliferative disorders and improves their classification.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>12580968</pmid><doi>10.1046/j.1365-2141.2003.04071.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Antigens, CD Antigens, Neoplasm - analysis B-Lymphocytes - immunology Biological and medical sciences Biomarkers, Tumor - analysis CD43 Diagnosis, Differential Hematologic and hematopoietic diseases Hematology Humans immunophenotype Immunophenotyping Leukemia, B-Cell - diagnosis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukosialin Lymphoma, B-Cell - diagnosis lymphoproliferative disorder Medical sciences Multivariate Analysis Neoplasm Proteins - analysis Sialoglycoproteins - analysis |
title | Cell surface CD43 determination improves diagnostic precision in late B‐cell diseases |
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