Cell surface CD43 determination improves diagnostic precision in late B‐cell diseases

Panels of immunological markers are useful in refining diagnosis in view of certain variability between B‐cell leukaemias. A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, C...

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Veröffentlicht in:	British journal of haematology 2003-02, Vol.120 (3), p.496-499
Hauptverfasser:	Jung, Georges, Eisenmann, Jean‐Claude, Thiébault, Sylvie, Hénon, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Antigens, Neoplasm - analysis B-Lymphocytes - immunology Biological and medical sciences Biomarkers, Tumor - analysis CD43 Diagnosis, Differential Hematologic and hematopoietic diseases Hematology Humans immunophenotype Immunophenotyping Leukemia, B-Cell - diagnosis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukosialin Lymphoma, B-Cell - diagnosis lymphoproliferative disorder Medical sciences Multivariate Analysis Neoplasm Proteins - analysis Sialoglycoproteins - analysis
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Zusammenfassung:	Panels of immunological markers are useful in refining diagnosis in view of certain variability between B‐cell leukaemias. A statistical multivariate approach was used on 100 B leukaemias (preliminary sample) to explore the potential value of the combination of CD43, and the classical markers CD5, CD23, CD79b, FMC7, CD22 and surface immunoglobulin to differentiate chronic lymphoid leukaemia (CLL) from lymphoma (non‐CLL). CD43 was highly effective (P
ISSN:	0007-1048 1365-2141
DOI:	10.1046/j.1365-2141.2003.04071.x