Mutation Screening and Association Analysis of the Parkin Gene in Parkinson’s Disease Patients from South-West China

Various deletions and point mutations in the Parkin gene have been strongly associated with Parkinson’s disease (PD) and parkinsonism, especially when the onset occurs at a young age. In this study, we screened 25 ‘early-onset’ (

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Bibliographische Detailangaben
Veröffentlicht in:	European neurology 2003-01, Vol.49 (2), p.85-89
Hauptverfasser:	Peng, Rong, Gou, Yinru, Yuan, Qiang, Li, Tao, Latsoudis, Helen, Yuan, Guanggu, Luo, Deru, Liu, Xiehe, Collier, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Catchment Area (Health) China - epidemiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Mutational Analysis Exons Female Gene Expression - genetics Gene Frequency Genotype Humans Ligases - genetics Male Mass Screening Medical sciences Middle Aged Neurology Original Paper Parkinson Disease - epidemiology Parkinson Disease - genetics Point Mutation - genetics Polymerase Chain Reaction Tropical medicine Ubiquitin-Protein Ligases
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Beschreibung
Zusammenfassung:	Various deletions and point mutations in the Parkin gene have been strongly associated with Parkinson’s disease (PD) and parkinsonism, especially when the onset occurs at a young age. In this study, we screened 25 ‘early-onset’ (
ISSN:	0014-3022 1421-9913
DOI:	10.1159/000068505