Mono- versus Bidentate Ligands in Rhodium-Catalyzed Asymmetric Hydrogenation. A Comparative Rate Study

Mono- versus Bidentate Ligands in Rhodium-Catalyzed Asymmetric Hydrogenation. A Comparative Rate Study

Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.

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Veröffentlicht in:Organic letters 2003-02, Vol.5 (4), p.475-478
Hauptverfasser: Peña, Diego, Minnaard, Adriaan J, de Vries, André H. M, de Vries, Johannes G, Feringa, Ben L
Format: Artikel
Sprache:eng
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Zusammenfassung:Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of α- or β-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol027457t