Synthesis of Nucleoside Dimers Bridged on Ribose with a Butadiynyl Group

Synthesis of Nucleoside Dimers Bridged on Ribose with a Butadiynyl Group

The nucleoside dimer linked by a butadiynediyl group at C-3‘β may serve as a building block for the preparation of backbone-modified oligonucleotides for DNA repair or mutation in functional genomics. We prepared this type of dimer by an Eglington or Sonogashira coupling reaction. The unsymmetrical...

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Veröffentlicht in:Organic letters 2003-02, Vol.5 (4), p.383-385
Hauptverfasser: Jung, Françoise, Burger, Alain, Biellmann, Jean-François
Format: Artikel
Sprache:eng
Schlagworte:
Acetylene - chemistry
Models, Molecular
Molecular Structure
Nucleosides - chemical synthesis
Ribose - chemistry
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Zusammenfassung:The nucleoside dimer linked by a butadiynediyl group at C-3‘β may serve as a building block for the preparation of backbone-modified oligonucleotides for DNA repair or mutation in functional genomics. We prepared this type of dimer by an Eglington or Sonogashira coupling reaction. The unsymmetrical dimer was synthesized by coupling the acetylene with the bromoacetylene. Only marginal cytotoxicity was detected for one of the dimers.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026584m