Lignans with Inhibitory Activity against NFAT Transcription from Schisandra chinensis

Abstract Seven lignans from SCHISANDRA CHINENSIS were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC 50 : 1.33 ± 0.05 μM) and schisandrol A (IC 50 : 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC 50 : 4.73 ± 0.09 μM), schisandrin A (IC 50 : 7.23 ± 0.2...

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Veröffentlicht in:	Planta medica 2003, Vol.69 (1), p.63-64
Hauptverfasser:	Lee, Im Seon, Lee, Hyeong-Kyu, Dat, Nguyen Tien, Lee, Mi Sun, Kim, Jung Woo, Na, Doe Sun, Kim, Young Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences DNA-Binding Proteins - antagonists & inhibitors General pharmacology Humans Jurkat Cells Letter Lignans - isolation & purification Lignans - pharmacology Medical sciences NFATC Transcription Factors Nuclear Proteins Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Schisandra - chemistry Transcription Factors - antagonists & inhibitors
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Zusammenfassung:	Abstract Seven lignans from SCHISANDRA CHINENSIS were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC 50 : 1.33 ± 0.05 μM) and schisandrol A (IC 50 : 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC 50 : 4.73 ± 0.09 μM), schisandrin A (IC 50 : 7.23 ± 0.21 μM), schisandrin C (IC 50 : 7.54 ± 0.22 μM), benzoylisogomisin O (IC 50 : 11.06 ± 1.02 μM) and schisandrol B (IC 50 : 16.37 ± 1.00 μM).
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2003-37024