Adrenomedullin stimulates somatostatin and thus inhibits histamine and acid secretion in the fundus of the stomach

Adrenomedullin has recently been localized to enterochromaffin-like (ECL) and chief cells in the gastric fundus. It has been proposed that adrenomedullin may play a role in gastric mucosal defense and repair. In the present study, we have used the isolated, luminally perfused mouse stomach and super...

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Veröffentlicht in:	Regulatory peptides 2003-02, Vol.110 (3), p.189-195
Hauptverfasser:	Hirsch, Ari B, McCuen, Robert W, Arimura, Akira, Schubert, Mitchell L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin Animals Biological and medical sciences Enzyme Inhibitors - metabolism Fundamental and applied biological sciences. Psychology Gastric Acid - metabolism Gastric Fundus - drug effects Gastric Fundus - metabolism Histamine - metabolism Hydrogen-Ion Concentration In Vitro Techniques Mice Peptides - pharmacology Rats Rats, Sprague-Dawley Somatostatin - metabolism Stomach Vertebrates: digestive system
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Zusammenfassung:	Adrenomedullin has recently been localized to enterochromaffin-like (ECL) and chief cells in the gastric fundus. It has been proposed that adrenomedullin may play a role in gastric mucosal defense and repair. In the present study, we have used the isolated, luminally perfused mouse stomach and superfused rat fundic segments to examine the effect of adrenomedullin on exocrine and endocrine secretion in this region of the stomach. Addition of adrenomedullin (1 pM to 1 μM) to the isolated mouse stomach caused a concentration-dependent decrease in acid secretion. The EC 50 value was 1.4×10 −9 and maximal inhibition of acid secretion was obtained at a concentration of 1 μM (31±4% below basal level, P
ISSN:	0167-0115 1873-1686
DOI:	10.1016/S0167-0115(02)00208-2