Cloning of the guinea pig 5-lipoxygenase gene and nucleotide sequence of its promoter

The guinea pig 5-lipoxygenase (5-LO) gene and its promoter were cloned from a guinea pig genomic DNA library. Sequencing analysis of the guinea pig promoter revealed that expression of the 5-LO gene in this rodent is probably governed by cis acting nucleotide sequences quite similar to the human gen...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-06, Vol.185 (2), p.489-495
Hauptverfasser:	Chopra, Arvind, Ferreira-Alves, Dalton L., Sirois, Pierre, Thirion, Jean-Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Arachidonate 5-Lipoxygenase - genetics Base Sequence Biological and medical sciences Blotting, Southern Cloning, Molecular Fundamental and applied biological sciences. Psychology Genes Genes. Genome Guinea Pigs Molecular and cellular biology Molecular genetics Molecular Sequence Data Promoter Regions, Genetic Regulatory Sequences, Nucleic Acid Restriction Mapping Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:	The guinea pig 5-lipoxygenase (5-LO) gene and its promoter were cloned from a guinea pig genomic DNA library. Sequencing analysis of the guinea pig promoter revealed that expression of the 5-LO gene in this rodent is probably governed by cis acting nucleotide sequences quite similar to the human gene. Nucleotide sequences that bind factors like Sp-1, AP-2, NF-kB and c-Ha- ras were identified in the guinea pig 5-LO promoter region.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(92)91651-6