Eukaryotic translation initiation factors and regulators

Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set...

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Veröffentlicht in:	Current opinion in structural biology 2003-02, Vol.13 (1), p.56-63
Hauptverfasser:	Sonenberg, Nahum, Dever, Thomas E
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Eukaryotic Initiation Factor-2 - chemistry Eukaryotic Initiation Factor-2 - metabolism Eukaryotic Initiation Factor-4E - chemistry Eukaryotic Initiation Factor-4E - metabolism Eukaryotic Initiation Factor-4G - genetics Eukaryotic Initiation Factor-4G - metabolism Eukaryotic Initiation Factors - chemistry Eukaryotic Initiation Factors - metabolism Gene Expression Regulation - physiology Homeostasis - physiology Macromolecular Substances Models, Molecular Phosphorylation Poly(A)-Binding Proteins - chemistry Poly(A)-Binding Proteins - metabolism Protein Binding Protein Biosynthesis - physiology Protein Conformation Protein Structure, Tertiary RNA, Ribosomal - chemistry RNA, Transfer - chemistry RNA, Transfer - metabolism
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Beschreibung
Zusammenfassung:	Significant progress has been made over the past several years on structural studies of the eukaryotic translation initiation factors that facilitate the assembly of a translation-competent ribosome at the initiation codon of an mRNA. These structural studies have revealed the repeated use of a set of common structural folds, highlighted the evolutionary conservation of the translation apparatus, and provided insight into the mechanism and regulation of cellular and viral protein synthesis.
ISSN:	0959-440X 1879-033X
DOI:	10.1016/S0959-440X(03)00009-5