Anticoagulant effects of sulphonated polyurethanes
Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by...
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| Veröffentlicht in: | Biomaterials 1992, Vol.13 (6), p.339-344 |
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| container_end_page | 344 |
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| container_title | Biomaterials |
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| creator | Silver, James H. Hart, Arlene P. Williams, Eliot C. Cooper, Stuart L. Charef, Said Labarre, Denis Jozefowicz, Marcel |
| description | Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma. |
| doi_str_mv | 10.1016/0142-9612(92)90037-O |
| format | Article |
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In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/0142-9612(92)90037-O</identifier><identifier>PMID: 1610956</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Anticoagulants - pharmacology ; Biocompatible Materials ; Biological and medical sciences ; Blood Coagulation - drug effects ; Blood-material interactions ; Dogs ; Fibrin - drug effects ; Fibrin - metabolism ; Humans ; In Vitro Techniques ; Materials Testing ; Medical sciences ; polyurethanes ; Polyurethanes - chemistry ; Polyurethanes - pharmacology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Sulfonic Acids - pharmacology ; sulphonates ; Technology. Biomaterials. Equipments. Material. Instrumentation ; Thrombin - antagonists & inhibitors</subject><ispartof>Biomaterials, 1992, Vol.13 (6), p.339-344</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-81950e9ba411313a3f5a2f5b6930a4a9cbcb021ac0ce7302f86afc327357360d3</citedby><cites>FETCH-LOGICAL-c301t-81950e9ba411313a3f5a2f5b6930a4a9cbcb021ac0ce7302f86afc327357360d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0142-9612(92)90037-O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4353412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1610956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silver, James H.</creatorcontrib><creatorcontrib>Hart, Arlene P.</creatorcontrib><creatorcontrib>Williams, Eliot C.</creatorcontrib><creatorcontrib>Cooper, Stuart L.</creatorcontrib><creatorcontrib>Charef, Said</creatorcontrib><creatorcontrib>Labarre, Denis</creatorcontrib><creatorcontrib>Jozefowicz, Marcel</creatorcontrib><title>Anticoagulant effects of sulphonated polyurethanes</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.</description><subject>Animals</subject><subject>Anticoagulants - pharmacology</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood-material interactions</subject><subject>Dogs</subject><subject>Fibrin - drug effects</subject><subject>Fibrin - metabolism</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>polyurethanes</subject><subject>Polyurethanes - chemistry</subject><subject>Polyurethanes - pharmacology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Sulfonic Acids - pharmacology</subject><subject>sulphonates</subject><subject>Technology. Biomaterials. Equipments. Material. Instrumentation</subject><subject>Thrombin - antagonists & inhibitors</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6ENFDdZL0Y3MRlsUvWNiLnkOaTtxKt6lJK-y_N6XLehMGwjDPOxkeQi4p3FOg2QPQhMUio-xWsDsBwPN4fUSmdJ7P41RAekymB-SUnHn_BaGHhE3IhGYURJpNCVs0XaWt-uxr1XQRGoO685E1ke_rdmMb1WEZtbbe9Q67jWrQn5MTo2qPF_t3Rj6en96Xr_Fq_fK2XKxizYF28ZyKFFAUKqGUU664SRUzaZEJDipRQhe6AEaVBo05B2bmmTKas5ynOc-g5DNyM-5tnf3u0XdyW3mNdTgUbe9lCAHPchbAZAS1s947NLJ11Va5naQgB1Vy8CAHD1KEGlTJdYhd7ff3xRbLv9DoJsyv93PltaqNU42u_AFLeMoTOvz-OGIYXPxU6KTXFTYay8oFl7K01f93_ALBboQA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Silver, James H.</creator><creator>Hart, Arlene P.</creator><creator>Williams, Eliot C.</creator><creator>Cooper, Stuart L.</creator><creator>Charef, Said</creator><creator>Labarre, Denis</creator><creator>Jozefowicz, Marcel</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Anticoagulant effects of sulphonated polyurethanes</title><author>Silver, James H. ; Hart, Arlene P. ; Williams, Eliot C. ; Cooper, Stuart L. ; Charef, Said ; Labarre, Denis ; Jozefowicz, Marcel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-81950e9ba411313a3f5a2f5b6930a4a9cbcb021ac0ce7302f86afc327357360d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Anticoagulants - pharmacology</topic><topic>Biocompatible Materials</topic><topic>Biological and medical sciences</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood-material interactions</topic><topic>Dogs</topic><topic>Fibrin - drug effects</topic><topic>Fibrin - metabolism</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Materials Testing</topic><topic>Medical sciences</topic><topic>polyurethanes</topic><topic>Polyurethanes - chemistry</topic><topic>Polyurethanes - pharmacology</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Sulfonic Acids - pharmacology</topic><topic>sulphonates</topic><topic>Technology. Biomaterials. Equipments. Material. Instrumentation</topic><topic>Thrombin - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silver, James H.</creatorcontrib><creatorcontrib>Hart, Arlene P.</creatorcontrib><creatorcontrib>Williams, Eliot C.</creatorcontrib><creatorcontrib>Cooper, Stuart L.</creatorcontrib><creatorcontrib>Charef, Said</creatorcontrib><creatorcontrib>Labarre, Denis</creatorcontrib><creatorcontrib>Jozefowicz, Marcel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silver, James H.</au><au>Hart, Arlene P.</au><au>Williams, Eliot C.</au><au>Cooper, Stuart L.</au><au>Charef, Said</au><au>Labarre, Denis</au><au>Jozefowicz, Marcel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticoagulant effects of sulphonated polyurethanes</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1992</date><risdate>1992</risdate><volume>13</volume><issue>6</issue><spage>339</spage><epage>344</epage><pages>339-344</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1610956</pmid><doi>10.1016/0142-9612(92)90037-O</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 1992, Vol.13 (6), p.339-344 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anticoagulants - pharmacology Biocompatible Materials Biological and medical sciences Blood Coagulation - drug effects Blood-material interactions Dogs Fibrin - drug effects Fibrin - metabolism Humans In Vitro Techniques Materials Testing Medical sciences polyurethanes Polyurethanes - chemistry Polyurethanes - pharmacology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sulfonic Acids - pharmacology sulphonates Technology. Biomaterials. Equipments. Material. Instrumentation Thrombin - antagonists & inhibitors |
| title | Anticoagulant effects of sulphonated polyurethanes |
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