Anticoagulant effects of sulphonated polyurethanes

Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by...

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Veröffentlicht in:	Biomaterials 1992, Vol.13 (6), p.339-344
Hauptverfasser:	Silver, James H., Hart, Arlene P., Williams, Eliot C., Cooper, Stuart L., Charef, Said, Labarre, Denis, Jozefowicz, Marcel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - pharmacology Biocompatible Materials Biological and medical sciences Blood Coagulation - drug effects Blood-material interactions Dogs Fibrin - drug effects Fibrin - metabolism Humans In Vitro Techniques Materials Testing Medical sciences polyurethanes Polyurethanes - chemistry Polyurethanes - pharmacology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sulfonic Acids - pharmacology sulphonates Technology. Biomaterials. Equipments. Material. Instrumentation Thrombin - antagonists & inhibitors
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Zusammenfassung:	Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma.
ISSN:	0142-9612 1878-5905
DOI:	10.1016/0142-9612(92)90037-O