Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents
A series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. Sy...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2003-02, Vol.13 (3), p.399-403 |
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| container_end_page | 403 |
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| container_issue | 3 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 13 |
| creator | Das, Saibal Kumar Reddy, K.Anantha Abbineni, Chandrasekhar Iqbal, Javed Suresh, J. Premkumar, M. Chakrabarti, Ranjan |
| description | A series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound
2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.
Synthesis and biological evaluation of
1 and
2 have been described. |
| doi_str_mv | 10.1016/S0960-894X(02)00976-9 |
| format | Article |
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2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.
Synthesis and biological evaluation of
1 and
2 have been described.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/S0960-894X(02)00976-9</identifier><identifier>PMID: 12565938</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Drug Design ; General and cellular metabolism. Vitamins ; Hypoglycemic Agents - chemical synthesis ; Hypoglycemic Agents - pharmacology ; Hypolipidemic Agents - chemical synthesis ; Hypolipidemic Agents - pharmacology ; Indicators and Reagents ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Oxazines - chemical synthesis ; Oxazines - pharmacology ; Pharmacology. Drug treatments ; Propionates - chemical synthesis ; Receptors, Cytoplasmic and Nuclear - drug effects ; Spectrophotometry, Infrared ; Structure-Activity Relationship ; Transcription Factors - drug effects ; Triglycerides - blood</subject><ispartof>Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.399-403</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-43daca0e6ac906a5147d34886695cc1921a53d1e70f569e7d32f32fd13b660a3</citedby><cites>FETCH-LOGICAL-c391t-43daca0e6ac906a5147d34886695cc1921a53d1e70f569e7d32f32fd13b660a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0960-894X(02)00976-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14500114$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12565938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Saibal Kumar</creatorcontrib><creatorcontrib>Reddy, K.Anantha</creatorcontrib><creatorcontrib>Abbineni, Chandrasekhar</creatorcontrib><creatorcontrib>Iqbal, Javed</creatorcontrib><creatorcontrib>Suresh, J.</creatorcontrib><creatorcontrib>Premkumar, M.</creatorcontrib><creatorcontrib>Chakrabarti, Ranjan</creatorcontrib><title>Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>A series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound
2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.
Synthesis and biological evaluation of
1 and
2 have been described.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Drug Design</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Hypoglycemic Agents - chemical synthesis</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - chemical synthesis</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Indicators and Reagents</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Oxazines - chemical synthesis</subject><subject>Oxazines - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Propionates - chemical synthesis</subject><subject>Receptors, Cytoplasmic and Nuclear - drug effects</subject><subject>Spectrophotometry, Infrared</subject><subject>Structure-Activity Relationship</subject><subject>Transcription Factors - drug effects</subject><subject>Triglycerides - blood</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFOGzEQhi0EKoH2EUB7oaKHhfGu7cSnqkLQVkLkAIferMGeDa6869TeoKZPj0kiOFYayZLnG8_vj7ETDhccuLq8B62gnmnx6xyaLwB6qmq9xyZcKFG3AuQ-m7whh-wo598AXIAQH9ghb6SSup1N2PwuPlOoxidPQ6ziX_znB6pwwBAXK8oVlhpG_7ReUlqEtaXe23LjquCX3lV9dKuAox8WFS5oGPNHdtBhyPRpdx6zh5vrh6sf9e38-8-rb7e1bTUfa9E6tAik0GpQKLmYulbMZkppaS3XDUfZOk5T6KTSVJpNV8rx9lEpwPaYfd4-u0zxT8k5mt5nSyHgQHGVzbTRuvxQFVBuQZtizok6s0y-x7Q2HMyrSLMRaV4tGWjMRqTRZe50t2D12JN7n9qZK8DZDsBsMXQJB-vzOydk0c1F4b5uOSo2nj0lk21xbcn5RHY0Lvr_RHkBm0aQnw</recordid><startdate>20030210</startdate><enddate>20030210</enddate><creator>Das, Saibal Kumar</creator><creator>Reddy, K.Anantha</creator><creator>Abbineni, Chandrasekhar</creator><creator>Iqbal, Javed</creator><creator>Suresh, J.</creator><creator>Premkumar, M.</creator><creator>Chakrabarti, Ranjan</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20030210</creationdate><title>Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents</title><author>Das, Saibal Kumar ; Reddy, K.Anantha ; Abbineni, Chandrasekhar ; Iqbal, Javed ; Suresh, J. ; Premkumar, M. ; Chakrabarti, Ranjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-43daca0e6ac906a5147d34886695cc1921a53d1e70f569e7d32f32fd13b660a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Drug Design</topic><topic>General and cellular metabolism. 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In vivo studies of the compounds indicated compound
2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed.
Synthesis and biological evaluation of
1 and
2 have been described.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12565938</pmid><doi>10.1016/S0960-894X(02)00976-9</doi><tpages>5</tpages></addata></record> |
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| ispartof | Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.399-403 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drug Design General and cellular metabolism. Vitamins Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - pharmacology Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - pharmacology Indicators and Reagents Magnetic Resonance Spectroscopy Medical sciences Mice Oxazines - chemical synthesis Oxazines - pharmacology Pharmacology. Drug treatments Propionates - chemical synthesis Receptors, Cytoplasmic and Nuclear - drug effects Spectrophotometry, Infrared Structure-Activity Relationship Transcription Factors - drug effects Triglycerides - blood |
| title | Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents |
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