Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

A series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. Sy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-02, Vol.13 (3), p.399-403
Hauptverfasser:	Das, Saibal Kumar, Reddy, K.Anantha, Abbineni, Chandrasekhar, Iqbal, Javed, Suresh, J., Premkumar, M., Chakrabarti, Ranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drug Design General and cellular metabolism. Vitamins Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - pharmacology Hypolipidemic Agents - chemical synthesis Hypolipidemic Agents - pharmacology Indicators and Reagents Magnetic Resonance Spectroscopy Medical sciences Mice Oxazines - chemical synthesis Oxazines - pharmacology Pharmacology. Drug treatments Propionates - chemical synthesis Receptors, Cytoplasmic and Nuclear - drug effects Spectrophotometry, Infrared Structure-Activity Relationship Transcription Factors - drug effects Triglycerides - blood
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Zusammenfassung:	A series of phenyl acetic acid and α-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. Synthesis and biological evaluation of 1 and 2 have been described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(02)00976-9