Regulation of the expression of adhesion molecules by human synoviocytes
The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined....
Gespeichert in:
| Veröffentlicht in: | Seminars in arthritis and rheumatism 1992-04, Vol.21 (5), p.330-334 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 334 |
|---|---|
| container_issue | 5 |
| container_start_page | 330 |
| container_title | Seminars in arthritis and rheumatism |
| container_volume | 21 |
| creator | Lindsley, Herbert B. Smith, Donald D. Davis, Laurie S. Koch, Alisa E. Lipsky, Peter E. |
| description | The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ⪢ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis. |
| doi_str_mv | 10.1016/0049-0172(92)90026-A |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72996204</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>004901729290026A</els_id><sourcerecordid>72996204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c386t-1644121b6f9c8909b91a1e7579ace6813f7a69165b9bf11e6e96a28f7078eda33</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimpN2SXMjjOEXDARR8C6k6amLtM1M2uH-vZ0b804InJDznJeTh5BToNdAgd9QmsqYgmCXkl1JShmPJ3tkCOOExRnn7_tkuEMOyVEIn5QCcCoGZNCXNGFiSB5f8KOrdGtdE7kyaucY4ffCYwjbF13M8fdeuwpNV2GI8lU072rdRGHVuKV1ZtViOCYHpa4CnmzriLzd371OH-PZ88PTdDKLTZLxNgaepsAg56U0maQyl6ABxVhIbZBnkJRCcwl8nMu8BECOkmuWlYKKDAudJCNyscldePfVYWhVbYPBqtINui4owaTkrP_diKQb0HgXgsdSLbyttV8poGotUK3tqLUdJfuzFqgm_djZNr_Layz-hjbG-v75tq-D0VXpdWNs2GHjJO1jocduNxj2LpYWvQrGYmOwsB5Nqwpn_9_jB3fPi-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72996204</pqid></control><display><type>article</type><title>Regulation of the expression of adhesion molecules by human synoviocytes</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Lindsley, Herbert B. ; Smith, Donald D. ; Davis, Laurie S. ; Koch, Alisa E. ; Lipsky, Peter E.</creator><creatorcontrib>Lindsley, Herbert B. ; Smith, Donald D. ; Davis, Laurie S. ; Koch, Alisa E. ; Lipsky, Peter E.</creatorcontrib><description>The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ⪢ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/0049-0172(92)90026-A</identifier><identifier>PMID: 1604327</identifier><identifier>CODEN: SAHRBF</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cell Adhesion Molecules - analysis ; Cell Adhesion Molecules - genetics ; Cell Adhesion Molecules - metabolism ; Diseases of the osteoarticular system ; Gene Expression Regulation - genetics ; Humans ; Inflammatory joint diseases ; Medical sciences ; Synovial Membrane - chemistry ; Synovial Membrane - cytology ; Synovial Membrane - metabolism</subject><ispartof>Seminars in arthritis and rheumatism, 1992-04, Vol.21 (5), p.330-334</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1644121b6f9c8909b91a1e7579ace6813f7a69165b9bf11e6e96a28f7078eda33</citedby><cites>FETCH-LOGICAL-c386t-1644121b6f9c8909b91a1e7579ace6813f7a69165b9bf11e6e96a28f7078eda33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-0172(92)90026-A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5340041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1604327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindsley, Herbert B.</creatorcontrib><creatorcontrib>Smith, Donald D.</creatorcontrib><creatorcontrib>Davis, Laurie S.</creatorcontrib><creatorcontrib>Koch, Alisa E.</creatorcontrib><creatorcontrib>Lipsky, Peter E.</creatorcontrib><title>Regulation of the expression of adhesion molecules by human synoviocytes</title><title>Seminars in arthritis and rheumatism</title><addtitle>Semin Arthritis Rheum</addtitle><description>The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ⪢ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.</description><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - analysis</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>Gene Expression Regulation - genetics</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Medical sciences</subject><subject>Synovial Membrane - chemistry</subject><subject>Synovial Membrane - cytology</subject><subject>Synovial Membrane - metabolism</subject><issn>0049-0172</issn><issn>1532-866X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimpN2SXMjjOEXDARR8C6k6amLtM1M2uH-vZ0b804InJDznJeTh5BToNdAgd9QmsqYgmCXkl1JShmPJ3tkCOOExRnn7_tkuEMOyVEIn5QCcCoGZNCXNGFiSB5f8KOrdGtdE7kyaucY4ffCYwjbF13M8fdeuwpNV2GI8lU072rdRGHVuKV1ZtViOCYHpa4CnmzriLzd371OH-PZ88PTdDKLTZLxNgaepsAg56U0maQyl6ABxVhIbZBnkJRCcwl8nMu8BECOkmuWlYKKDAudJCNyscldePfVYWhVbYPBqtINui4owaTkrP_diKQb0HgXgsdSLbyttV8poGotUK3tqLUdJfuzFqgm_djZNr_Layz-hjbG-v75tq-D0VXpdWNs2GHjJO1jocduNxj2LpYWvQrGYmOwsB5Nqwpn_9_jB3fPi-w</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>Lindsley, Herbert B.</creator><creator>Smith, Donald D.</creator><creator>Davis, Laurie S.</creator><creator>Koch, Alisa E.</creator><creator>Lipsky, Peter E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920401</creationdate><title>Regulation of the expression of adhesion molecules by human synoviocytes</title><author>Lindsley, Herbert B. ; Smith, Donald D. ; Davis, Laurie S. ; Koch, Alisa E. ; Lipsky, Peter E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1644121b6f9c8909b91a1e7579ace6813f7a69165b9bf11e6e96a28f7078eda33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - analysis</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Diseases of the osteoarticular system</topic><topic>Gene Expression Regulation - genetics</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Medical sciences</topic><topic>Synovial Membrane - chemistry</topic><topic>Synovial Membrane - cytology</topic><topic>Synovial Membrane - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindsley, Herbert B.</creatorcontrib><creatorcontrib>Smith, Donald D.</creatorcontrib><creatorcontrib>Davis, Laurie S.</creatorcontrib><creatorcontrib>Koch, Alisa E.</creatorcontrib><creatorcontrib>Lipsky, Peter E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindsley, Herbert B.</au><au>Smith, Donald D.</au><au>Davis, Laurie S.</au><au>Koch, Alisa E.</au><au>Lipsky, Peter E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of the expression of adhesion molecules by human synoviocytes</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><addtitle>Semin Arthritis Rheum</addtitle><date>1992-04-01</date><risdate>1992</risdate><volume>21</volume><issue>5</issue><spage>330</spage><epage>334</epage><pages>330-334</pages><issn>0049-0172</issn><eissn>1532-866X</eissn><coden>SAHRBF</coden><abstract>The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ⪢ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>1604327</pmid><doi>10.1016/0049-0172(92)90026-A</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-0172 |
| ispartof | Seminars in arthritis and rheumatism, 1992-04, Vol.21 (5), p.330-334 |
| issn | 0049-0172 1532-866X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72996204 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Cell Adhesion Molecules - analysis Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Diseases of the osteoarticular system Gene Expression Regulation - genetics Humans Inflammatory joint diseases Medical sciences Synovial Membrane - chemistry Synovial Membrane - cytology Synovial Membrane - metabolism |
| title | Regulation of the expression of adhesion molecules by human synoviocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T17%3A12%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20the%20expression%20of%20adhesion%20molecules%20by%20human%20synoviocytes&rft.jtitle=Seminars%20in%20arthritis%20and%20rheumatism&rft.au=Lindsley,%20Herbert%20B.&rft.date=1992-04-01&rft.volume=21&rft.issue=5&rft.spage=330&rft.epage=334&rft.pages=330-334&rft.issn=0049-0172&rft.eissn=1532-866X&rft.coden=SAHRBF&rft_id=info:doi/10.1016/0049-0172(92)90026-A&rft_dat=%3Cproquest_cross%3E72996204%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72996204&rft_id=info:pmid/1604327&rft_els_id=004901729290026A&rfr_iscdi=true |