Regulation of the expression of adhesion molecules by human synoviocytes

The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined....

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Veröffentlicht in:Seminars in arthritis and rheumatism 1992-04, Vol.21 (5), p.330-334
Hauptverfasser: Lindsley, Herbert B., Smith, Donald D., Davis, Laurie S., Koch, Alisa E., Lipsky, Peter E.
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Sprache:eng
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Zusammenfassung:The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ⪢ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.
ISSN:0049-0172
1532-866X
DOI:10.1016/0049-0172(92)90026-A