Seco diterpenoids from Excoecaria agallocha L

Chemical examination of the ethyl acetate solubles of the CH 3OH:CH 2Cl 2 (1:1) extract of the roots of Excoecaria agallocha L. collected from Godavary estuary resulted in the isolation of three more new diterpenoids, agallochins M–O ( 1–3). The structures of the new diterpenoids were elucidated by a study of their physical and spectral data as methyl ent-13- epi-8,13-epoxy-4,6α-dihydroxy-3,4-secolabd-14-en-3-oate ( 1), methyl ent-13- epi-8,13-epoxy-2,3-secolabd-14-en-2,11-olid-3-oate ( 2), and methyl ent-17-hydroxy-3,4-secokaura-4(19),15-dien-3-oate ( 3). Three seco diterpenoids agallochin M ( 1), agallochin N ( 2), and agallochin O ( 3) were isolated from the mangrove plant Excoecaria agallocha L.