Palladium-Catalyzed Amination of Aryl Bromides with Hindered N-Alkyl-Substituted Anilines Using a Palladium(I) Tri-tert-butylphosphine Bromide Dimer

Palladium-Catalyzed Amination of Aryl Bromides with Hindered N-Alkyl-Substituted Anilines Using a Palladium(I) Tri-tert-butylphosphine Bromide Dimer

An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)2 and P(t-Bu)3 or a palladium(I) tri-tert-butylphosphine bromide dimer, [Pd(μ-Br)(t-Bu3P)]2, a new, commercially available, and easily handl...

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Veröffentlicht in:Journal of organic chemistry 2003-02, Vol.68 (3), p.1163-1164
Hauptverfasser: Prashad, Mahavir, Mak, Xiao Yin, Liu, Yugang, Repič, Oljan
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
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Zusammenfassung:An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)2 and P(t-Bu)3 or a palladium(I) tri-tert-butylphosphine bromide dimer, [Pd(μ-Br)(t-Bu3P)]2, a new, commercially available, and easily handled catalyst.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo020609d