D1 receptor alleles predict PET metabolic correlates of clinical response to clozapine

A goal of pharmacogenetics is to clarify associations between allelic variation and risk factors in psychiatric illness. We report changes in regional brain metabolism based on dopamine alleles. Treatment-resistant schizophrenic subjects were positron emission tomography scanned with 18F-fluorodeoxy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular psychiatry 2003, Vol.8 (1), p.109-113
Hauptverfasser:	Potkin, S G, Basile, V S, Jin, Y, Masellis, M, Badri, F, Keator, D, Wu, J C, Alva, G, Carreon, D T, Bunney, W E, Fallon, J H, Kennedy, J L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Alleles Antipsychotic Agents - administration & dosage Behavioral Sciences Biological and medical sciences Biological Psychology Brain - diagnostic imaging Brain - drug effects Brain - physiology Clozapine - administration & dosage Female Genotype Humans Male Medical sciences Medicine Medicine & Public Health Neurosciences original-research-article Pharmacotherapy Predictive Value of Tests Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, Dopamine D1 - genetics Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Schizophrenia - genetics Tomography, Emission-Computed
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A goal of pharmacogenetics is to clarify associations between allelic variation and risk factors in psychiatric illness. We report changes in regional brain metabolism based on dopamine alleles. Treatment-resistant schizophrenic subjects were positron emission tomography scanned with 18F-fluorodeoxyglucose after 5 weeks each of placebo and clozapine treatment. Significant regional brain metabolic effects were found for the D1 receptor genotypes ( P
ISSN:	1359-4184 1476-5578
DOI:	10.1038/sj.mp.4001191