The outcome of in vitro fertilization and embryo transfer in women with polycystic ovary syndrome failing to conceive after ovulation induction with exogenous gonadotropins

To assess the outcome of in vitro fertilization and embryo transfer (IVF-ET) in women with refractory polycystic ovarian syndrome (PCOS). Retrospective case series with an age-matched control group. Ovulation induction and IVF programs in a tertiary referral center. Nine patients with PCOS who faile...

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Veröffentlicht in:Fertility and sterility 1992-06, Vol.57 (6), p.1269-1273
Hauptverfasser: Urman, Bulent, Fluker, Margo R., Yuen, Basil Ho, Fleige-Zahradka, Bettina G., Zouves, Christo G., Moon, Young S.
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Sprache:eng
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Zusammenfassung:To assess the outcome of in vitro fertilization and embryo transfer (IVF-ET) in women with refractory polycystic ovarian syndrome (PCOS). Retrospective case series with an age-matched control group. Ovulation induction and IVF programs in a tertiary referral center. Nine patients with PCOS who failed standard ovulation induction treatment (clomiphene citrate plus ≥6 ovulatory human menopausal gonadotropin [hMG] cycles) underwent 19cycles of IVF-ET. Forty age-matched tubal factor patients who completed 40cycles of IVF-ET served as a control group. Demographic features and IVF-ET cycle characteristics were compared using Student’s t-test and Fisher’s exact test. Cycles of IVF-ET in patients with PCOS were associated with higher estradiol levels (5,222 versus 4,009 pmol/L), lower hMG requirements (15.8 versus 19.6 vials), greater numbers of oocytes (7.6 versus 5.6), and lower fertilization rates (56% versus 75%) compared with tubal factor cycles (P
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)55086-9