Administration of growth hormone to patients with advanced cardiac heart failure: effects upon left ventricular function, exercise capacity, and neurohormonal status

Experimental and clinical studies have shown that the administration of recombinant human growth hormone can improve deteriorated left ventricular function and hemodynamics in patients with heart failure. Herein, we compared the effects of growth hormone versus placebo upon resting left ventricular...

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Veröffentlicht in:	International journal of cardiology 2003-02, Vol.87 (2), p.185-191
Hauptverfasser:	Acevedo, Mónica, Corbalán, Ramón, Chamorro, Gastón, Jalil, Jorge, Nazzal, Carolina, Campusano, Claudia, Castro, Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Cardiac function Double-Blind Method Drug Administration Schedule Exercise Tolerance - drug effects Female Follow-Up Studies Growth hormone Heart failure Heart Failure - diagnosis Heart Failure - drug therapy Heart Failure - mortality Heart Function Tests Hormones. Endocrine system Human Growth Hormone - administration & dosage Humans Injections, Subcutaneous Insulin like growth factor-1 Insulin-Like Growth Factor I - analysis Male Medical sciences Middle Aged Neurohormonal status Oxygen Consumption Pharmacology. Drug treatments Reference Values Risk Assessment Severity of Illness Index Statistics, Nonparametric Survival Rate Treatment Outcome Ventricular Function, Left - drug effects
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Beschreibung
Zusammenfassung:	Experimental and clinical studies have shown that the administration of recombinant human growth hormone can improve deteriorated left ventricular function and hemodynamics in patients with heart failure. Herein, we compared the effects of growth hormone versus placebo upon resting left ventricular ejection fraction, exercise capacity and neurohormonal status in patients with advanced heart failure. Nineteen patients with advanced cardiac heart failure (ejection fraction
ISSN:	0167-5273 1874-1754
DOI:	10.1016/S0167-5273(02)00249-8