Mild and Highly Chemoselective Oxidation of Thioethers Mediated by Sc(OTf)3

Mild and Highly Chemoselective Oxidation of Thioethers Mediated by Sc(OTf)3

Catalytic Sc(OTf)3 greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl−aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with min...

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Veröffentlicht in:Organic letters 2003-02, Vol.5 (3), p.235-237
Hauptverfasser: Matteucci, Mizio, Bhalay, Gurdip, Bradley, Mark
Format: Artikel
Sprache:eng
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Zusammenfassung:Catalytic Sc(OTf)3 greatly increases the efficiency of hydrogen peroxide mediated monooxidation of alkyl−aryl sulfides and methyl cysteine containing peptides. The method is high yielding, compatible with many widely used protecting groups, suitable for solid-phase applications and proceeds with minimum over-oxidation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol026947i