Enhanced vasodilatory responses to bradykinin in stroke-prone spontaneously hypertensive rats

Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from S...

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Veröffentlicht in:	European journal of pharmacology 1992-01, Vol.210 (2), p.217-219
Hauptverfasser:	Stier, Charles T., Selig, Nicola, Itskovitz, Harold D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Bradykinin Bradykinin - pharmacology Cardiology. Vascular system Cerebrovascular Disorders - genetics Disease Susceptibility Experimental diseases Hypertension - genetics Hypertension - physiopathology In Vitro Techniques Kidney - drug effects Male Medical sciences Rats Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WKY Renal vasodilation Spontaneously hypertensive rat, stroke prone (SHR/SP) Vasodilator Agents - pharmacology
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Zusammenfassung:	Vasodilatory responses to bradykinin (BK) and acetylcholine (ACh) were compared in phenylephrine preconstricted perfused kidneys from 30-week-old male stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). Responses to ACh did not differ between kidneys from SHRSP and WHY. BK-induced dilatation was greater in kidneys from SHRSP relative to WHY and was not affected by indomethacin or captopril. These results indicate that renal vasodilatory responsiveness to bradykinin is enhanced in SHRSP with established hypertension.
ISSN:	0014-2999 1879-0712
DOI:	10.1016/0014-2999(92)90675-T